MOTS-C

Peptides

Updated : May 10, 2026

Class: Mitochondrial-Derived Peptide

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-encoded peptide that regulates metabolic homeostasis. It activates AMPK pathways, enhances glucose uptake, and has demonstrated remarkable anti-aging and exercise-mimetic properties in preclinical and early clinical research.

Key Benefits

Activates AMPK – the cellular energy sensor

Improves insulin sensitivity and glucose metabolism

Anti-aging and longevity-promoting properties

Enhanced physical performance and endurance

Standard Dosage Scheduled

Parameter

Details

Dose

5-10 mg subcutaneous or IV injection

Frequency

2-3 times per week

Common Protocol

5 mg, 2-3x/week for 4-8 weeks

Timing

Morning, ideally before exercise

Cycle

8-12 weeks on, 4 weeks off

MOTS-C

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MOTS-C

Standard Dosage Scheduled

MOTS-C

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