5-Amino-1MQ is a small molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT), an enzyme that
regulates cellular energy metabolism and fat storage. By inhibiting NNMT, 5-Amino-1MQ raises intracellular
NAD+ levels, activates SIRT1, and shifts cellular metabolism toward fat oxidation. It has demonstrated
significant potential for obesity, metabolic syndrome, and as a potent longevity-supporting compound.
Key Benefits
• Inhibits NNMT — raises intracellular NAD+ and activates SIRT1
• Promotes fat cell (adipocyte) shrinkage and lipolysis
• Improves insulin sensitivity and metabolic flexibility
• Anti-obesity effects demonstrated in preclinical models
• Synergistic with NAD+ precursors and caloric restriction protocols
