PT-141

Peptides

Updated : May 10, 2026

Class: Melanocortin Receptor Agonist / Sexual Function Peptide

PT-141 is a synthetic analogue of alpha-MSH acting on melanocortin receptors (MC3R and MC4R) in the CNS to stimulate sexual arousal and desire. Unlike PDE5 inhibitors, PT-141 works centrally – addressing desire at the neurological level making it effective for both men and women. FDA-approved (as Vyleesi) for HSDD in premenopausal women.

Key Benefits

  • Centrally acting
  • stimulates sexual desire and arousal at the brain level
  • Effective in both men and women
  • FDA-approved analogue for HSDD in women (Vyleesi)
  • Works independently of vascular mechanisms
  • Enhanced sexual satisfaction and performance

Standard Dosage Scheduled

Parameter

Details

Dose

0.5-2 mg subcutaneous injection

Timing

45-60 minutes before sexual activity

Administration

Subcutaneous injection, abdomen or thigh

Frequency

As needed not for daily use

Note

Start at 0.5-1 mg to assess tolerance; nausea possible at higher doses

PT-141

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