Retatrutide

Peptides

Updated : May 10, 2026

Class: GIP/GLP-1/Glucagon Triple Agonist

Retatrutide is a next-generation triple receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. It demonstrates superior weight loss efficacy compared to dual or single agonists, making it one of the most potent peptides in development for metabolic health, obesity management, and cardiometabolic disease.

Key Benefits

  • Significant body weight reduction (up to 24% in clinical trials)
  • Improved insulin sensitivity and glycemic control
  • Reduction in liver fat and visceral adiposity
  • Favorable cardiovascular risk profile
  • Appetite suppression and reduced caloric intake

Standard Dosage Scheduled

Parameter

Details

Starting Dose

2 mg subcutaneous injection, once weekly

Titration (Weeks 4-8)

4 mg once weekly

Maintenance

8-12 mg once weekly (based on tolerance)

Injection Site

Abdomen, thigh, or upper arm - rotate sites

Cycle Length

24-36 weeks, followed by reassessment

Retatrutide

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